Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Highlights • D1 and D2 neuron activity in the NAc is elevated during behavioral suppression • Inhibition of D1 or D2 neurons in the NAc increases unproductive reward seeking • BLA and PVT axons innervate distinct NAc subregions, yet both inputs are reinforcing • Inhibition of BLA or PVT inputs to the NAc increases unproductive reward seeking Summary The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear.
Highlights • Operant choice behavior is driven by differences in expected value • Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value • Disrupting cue-evoked DA interferes with the maintenance of cue-value associations • Manipulations of cue-evoked DA signaling do not lead to under- or overexpectation Summary Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value, but its influence on reward assessment is unclear.
Reward-seeking behavior is regulated by a diverse collection of inputs to the nucleus accumbens (NAc). The information encoded in each excitatory afferent to the NAc is unknown, in part because it is unclear when these pathways are active in relation to behavior. Here we compare the activity profiles of amygdala, hippocampal, and thalamic inputs to the NAc shell in mice performing a cued reward-seeking task using GCaMP-based fiber photometry.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
