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Limited field radiation therapy results in decreased bone fracture toughness in a murine model

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By Kenneth Mann, Timothy Damron, Christopher M. Bartlow, Megan E. Oest
| PLOS
Fragility fractures are a well-known complication following oncologic radiotherapy, and it is suspected that radiation-induced embrittlement of bone within the treatment field may contribute to fracture risk. To explore this phenomenon, a mouse model (BALB/cJ) of fractionated, limited field, bilateral hindlimb irradiation (4x5 Gy) was used.
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