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Articles by Christopher Steer
Olaparib in HR-deficient, metastatic triple-negative breast and platinum-sensitive relapsed ovarian cancers without germline mutations in BRCA1/2 : phase 2 EMBRACE trial
Abstract Homologous recombination (HR) deficiency (HRD) from germline BRCA1/2 mutations (gBRCAm) sensitizes high-grade serous ovarian cancer (HGSOC) and triple-negative breast cancer (TNBC) to PARP inhibitors (PARPi), as may promoter methylation of BRCA1 (meBRCA1) or RAD51C (meRAD51C) or mutation of non-BRCA HR genes. This trial evaluated olaparib in platinum-sensitive, relapsed HGSOC (PSROC) and metastatic TNBC (mTNBC) with non-gBRCA HRD.
The Utility of Molecular Tumor Profiling for Patients With Advanced or Rare Cancer in a Regional Australian Setting
Aim Molecular tumor profiling (MTP) aims to link biomarker targets to corresponding treatments, usually via clinical trials. The usefulness of offering MTP for patients in a regional/rural setting is unknown, including assessment of outcomes of commencement on a clinical trial and potential cost savings.
Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary - Nature Communications
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Abstract Genomics can inform both tissue-of-origin (TOO) and precision treatments for patients with cancer of unknown primary (CUP). Here, we use whole genome and transcriptome sequencing (WGTS) for 72 patients and show diagnostic superiority of WGTS over panel testing (386–523 genes) in 71 paired cases. WGTS detects all reportable DNA features found by panel as well as additional mutations of diagnostic or therapeutic relevance in 76% of cases.
By Richard J. Rebello, Atara Posner, Ruining Dong, Camilla B. Mitchell, Catherine Mitchell, Sehrish Kanwal, Hui-Li Wong, Shiva Balachander, Shannon Nicolson, Anna deFazio, Ian Collins, Christopher Steer, Andrew Fellowes, Rodney Hicks, Charles Shale, Sarah-Jane Dawson, Stephen Fox, Sean Grimmond, Linda Mileshkin
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Nature
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MPs | Free Full-Text | Geriatric Oncology in the Instagram Era: Feasibility and Acceptability Randomised Controlled Trial on Adopting PhotoVoice to Enable Empowerment, Patient-Centred Care, and Shared Decision Making-Study Protocol
Open AccessProtocol by Christopher Steer 1,2,3, Tshepo Rasekaba 1,*, Kylie Owen 4, Darren Jayasuriya 3, Mira Kapur 3, Kim Young 1, Nicole Webb 2 and Irene Blackberry 1,5 1 John Richards Centre for Rural Ageing Research, La Trobe Rural Health School, La Trobe University, Albury-Wodonga, VIC 3690, Australia 2 Border Medical Oncology and Haematology, Albury-Wodonga, NSW 2640, Australia 3 School of Clinical Medicine, Rural Clinical Campus, University of New South Wales, Albury, NSW 2640,...
Infections, resistance patterns and antibiotic use in patients at a regional cancer centre
Infections and antibiotic resistance patterns in patients attending regional Australian cancer centres are poorly described. To document patient characteristics, infection types, patterns of antibiotic resistance and outcomes in all patients with cancer requiring inpatient management for suspected infection at a regional Australian cancer centre.
Infections, Resistance Patterns and Antibiotic Use in Patients at a Regional Cancer Centre
To document patient characteristics, infection types, patterns of antibiotic resistance and outcomes in all patients with cancer requiring inpatient management for suspected infection at a regional Australian cancer centre. We studied patients???18?years of age who were admitted under the oncology unit at Albury Wodonga Health during a 12-month period and who had a microbiological test performed for suspected infection during their admission.
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