Skip to main content
Shannon Nicolson on Muck Rack

Shannon Nicolson

As seen in: Nature

Get in touch with Shannon

Contact Shannon, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Articles

Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary - Nature Communications

|
By Richard J. Rebello, Atara Posner, Ruining Dong, Camilla B. Mitchell, Catherine Mitchell, Sehrish Kanwal, Hui-Li Wong, Shiva Balachander, Shannon Nicolson, Anna deFazio, Ian Collins, Christopher Steer, Andrew Fellowes, Rodney Hicks, Charles Shale, Sarah-Jane Dawson, Stephen Fox, Sean Grimmond, Linda Mileshkin
| Nature Verified
Abstract Genomics can inform both tissue-of-origin (TOO) and precision treatments for patients with cancer of unknown primary (CUP). Here, we use whole genome and transcriptome sequencing (WGTS) for 72 patients and show diagnostic superiority of WGTS over panel testing (386–523 genes) in 71 paired cases. WGTS detects all reportable DNA features found by panel as well as additional mutations of diagnostic or therapeutic relevance in 76% of cases.
Open in Who Shared Issue with article?
See all 1 articles