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Keywords Th17 IL-23R CHD1 GR EAE phosphoproteomics steroid resistance Introduction CD4+IL-17-producing T helper cells (Th17) that exhibit a nonpathogenic phenotype maintain tissue homeostasis (Th17Hom); however, upon exposure to interleukin 23 (IL-23), they can differentiate into pro-inflammatory Th17 cells (Th17Inf)1,2 that can defend against fungal infections and can also drive autoimmune tissue inflammation.3 IL-23, a member of the IL-12 cytokine family, signals through a heterodimeric...
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