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Articles by Christopher Wu
Fixational saccades and drift parameters are altered in poorly controlled type 2 diabetes mellitus: a pilot study
Abstract Type 2 diabetes mellitus (T2DM) is a prevalent metabolic condition associated with neuronal and vascular complications across multiple organ systems, including the eye, leading to vision impairment. Evidence suggests that structural and functional deficits may arise before funduscopically detectable changes in T2DM. Fixational eye movements (FEMs) reflect the integrity of the oculomotor control systems and may serve as early functional markers of neurological dysfunction.
AI 写代码越来越强，但它不知道我们上周修了什么 bug，把 Bug 重新引入生产环境了
三个月前，我们花了两周时间修了一个 bug 。 用户账单偶尔会出现 ¥0.01 的误差。复现不稳定，线上偶发，客服一直在手动补差价。翻遍了日志，最后定位到一个经典问题：浮点数精度。 0.1 + 0.2 在 IEEE 754 里不等于 0.3，这个大家都听说过，但真的踩到还是很痛。 修复方案是把所有金额改成以「分」为单位存整数，展示时再除以 100 。改动不复杂，但涉及的地方很多，改完之后代码里到处是 amount * 100、Math.round()、/ 100，看起来有点丑，但能用，bug 消失了。 然后上个月，我让 Agent 帮我重构结算模块，优化一下代码结构。 它看到那堆乘除，觉得多此一举，顺手给「简化」了，改回了直接用浮点数。逻辑更清晰，代码更短，单元测试全过。 那个 ¥0.01 的 bug 悄悄回来了。 这件事让我开始认真想一个问题： 我们有代码审查，但我们需要「意图审查」。 这不是 AI 写了烂代码 大家讨论 AI 写代码，通常聚焦在输出质量上：架构合不合理、有没有 bug 、测试过了没有。 但我说的这个问题不一样。 Agent...
做了个小工具，处理 coding agent 的决策冲突
AI coding 有时候会遇到问题： agent 经常不知道以前为什么放弃过某个方案，也不知道别人正在用 agent 做些什么。结果就是它可能把历史上已经否掉的方案重新做回来，或者提交代码后才发现和别人的 agent 写的东西有逻辑冲突。 我把这个问题叫 coding agent 的决策冲突：它不是代码层面的冲突，而是“意图（ intent ）”的冲突。 Mainline 的思路是把这些 intent / decision 记录到 Git 里。agent 开始改之前先读相关历史和当前 intent ，改完以后再留下一条新的记录。 这个项目自己也是这么自举出来的。中途加入的小伙伴把代码 clone 下来，看一下本地生成的 Hub 里的历史记录和当前 intent ，基本就能知道项目为什么走到现在这样、现在大家各自在改什么，不用先靠人肉同步一大堆上下文。 下面是我们自己项目里生成的静态 Hub 视图。 详情可见： https://mainline.sh https://github.com/mainline-org/mainline
我做了个工具防止 AI agent 在不熟悉的代码里乱改 — 找几个内测
最近 dogfood 一个工具叫 mainline ，分享一下做这个的真实故事，顺便看 V2EX 上有没有人感兴趣内测。 起因 我在公司推团队用 AI 编程，作为 staff engineer 写过内部 guideline 。过程中发现一个反复出现的现象： AI agent 写出的代码不是"明显错"——是"看起来合理，但基于错误的历史前提"。 具体例子： repo 里有个半成品的 Redis 队列：redis.go 、TODO 注释、docker-compose 里也配了 redis 。Claude Code 看到这些，合理地想把这个实现完。 但实际情况——这个团队 3 周前已经放弃 Redis 了，因为 replication 延迟导致 billing 事件重复。这个决定散在某个 PR 评论里、Slack 几条消息、几个工程师脑子里。 代码搜索能看到 redis 文件——但看不到那个决定。 先尝试过现成方案 AGENTS.md / CLAUDE.md 写 not-todo——能写"don't use redis"，但只解决你能预判到的。新决定一直在产生，没人持续维护。 ADR...
Q-MRS: Quantitative Magnetic Resonance Spectral Analysis Using Deep Learning
C. J.Wu, L. S.Kegeles, D. L.Rothman, and J.Guo, “Q-MRS: Quantitative Magnetic Resonance Spectral Analysis Using Deep Learning,” NMR in Biomedicine39, no. 5 (2026): e70279, https://doi.org/10.1002/nbm.70279. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The in vivo dataset used in this study can be downloaded from https://www.nitrc.org/projects/biggaba.
[自荐] 找回 90 年代换台的感觉：我写了个复古电视风的 B 站“冲浪”播放器
主题：[自荐] BiliTV - 找回儿时守在电视机前“不断换台”的快乐 各位 V 友， 最近我燃烧 token ，用 AI 做了一个小项目 BiliTV。起因是觉得现在的视频 App 互动太重，算法推荐虽然精准，但总觉得少了点小时候那种“漫无目的调台、刚好撞见好节目”的惊喜感。 于是，我把 B 站的视频流塞进了一个“复古大头电视”里。 BiliTV 是一个模拟复古电视交互的 Web 播放器。它不是简单的嵌入，而是从视觉到操作逻辑都在还原“看电视”的体验。 沉浸式 UI： 带有复古电视外壳、OSD 频道指示、扫描线 (Scanline) 和模拟噪点。 真·换台感： 切换频道时有短暂的“雪花噪声”插播，支持键盘 ↑ / ↓ 盲操作。 频道系统： 预设了多个主题频道，支持直接粘贴 BVID 列表导入成自己的专属频道。 极简交互： 支持“无鼠标模式”和遥控器弹窗，甚至可以配合手机端模拟远程控制。 开关机特效： 还原了老式电视那种从中心缩放熄灭的仪式感。 Frontend: 原生感极强的 UI + CSS 滤镜实现扫描线效果。 Backend: Express API...
Characteristics of spatial summation in the magnocellular, parvocellular, and koniocellular pathways
Abstract In this study, we characterize the spatial summation properties of targeted magnocellular, parvocellular, and koniocellular pathways within the central 20 degrees of visual field using chromatic transformations in DKL color space. For the magnocellular and koniocellular conditions, critical areas of complete spatial summation were found for all eccentricities. For the parvocellular conditions, complete spatial summation was absent within the stimulus size ranges tested.
Arrays vs Linked Lists: The battle finally settled
The two most well-known and used data structures. Interviewers love grilling you on your knowledge of arrays and linked lists, often to gauge your understanding of when to use them, which one is better for a specific scenario, and how one might be used to optimize for another. Demonstrating your knowledge of them can be a good first indicator to them that you take optimization and factoring in trade offs into consideration when developing applications.
Should You Care About SD Card Speeds?
It’s easy to overlook the speed of your SD cards, but choosing the right one can enhance your gaming, photography, and high-resolution video recording experiences. If you haven’t considered the speed ratings of your cards, it might be time to start! Check out sdcardsupply.com for a filterable listing of SD cards on Amazon and their specs. Why Should You Care About SD Card Speeds It’s important to understand why SD card speeds could be significant.
Addition of dexamethasone to prolong peripheral nerve blocks: a ChatGPT-created narrative review
http://orcid.org/0000-0002-4484-0787Christopher L Wu1,2,3, Brian Cho4, http://orcid.org/0000-0003-4443-0021Rodney Gabriel5, Robert Hurley6, http://orcid.org/0000-0002-1029-2786Jiabin Liu7, http://orcid.org/0000-0003-2735-248XEdward R Mariano8,9, Vineesh Mathur4, Stavros G Memtsoudis1,2 and Michael Conrad Grant4 1Department of Anesthesiology, Critical Care Medicine and Pain Management, Hospital for Special Surgery, New York, New York, USA 2Anesthesiology, Weill Cornell Medicine, New York, New...
From Gutter Cats to Great Cats
Smithsonian Voices From the Smithsonian Museums OFFICE OF ACADEMIC APPOINTMENTS AND INTERNSHIPS The Journey of Craig Saffoe, Curator of Great Cats at the Smithsonian’s National Zoo Ever heard of a gutter cat?
Ethnic Differences in Western and Asian Sacroiliac Joint Anatomy for Surgical Planning of Minimally Invasive Sacroiliac Joint Fusion
Abstract : Pain originating in the sacroiliac joint (SIJ) is a contributor to chronic lower back pain. Studies on minimally invasive SIJ fusion for chronic pain have been performed in Western populations. Given the shorter stature of Asian populations compared with Western populations, questions can be raised regarding the suitability of the procedure in Asian patients.
Characterizing the Chemical Profile of Biological Decline in Stormwater-Impacted Urban Watersheds
Chemical contamination is an increasingly important conservation issue in urban runoff-impacted watersheds. Regulatory and restoration efforts typically evaluate limited conventional parameters and pollutants. However, complex urban chemical mixtures contain hundreds to thousands of organic contaminants that remain unidentified, unregulated, and poorly understood.
‘Green-gional’ anesthesia: further considerations
‘Green-gional’ anesthesia: further considerations Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. Copyright information: © American Society of Regional Anesthesia & Pain Medicine 2020. No commercial re-use. See rights and permissions.
'Green-gional' anesthesia: the non-polluting benefits of regional anesthesia to decrease greenhouse gases and attenuate climate change
'Green-gional' anesthesia: the non-polluting benefits of regional anesthesia to decrease greenhouse gases and attenuate climate change Free Mausam Kuvadia1,2, Cynthia Eden Cummis3, Gregory Liguori1 and http://orcid.org/0000-0002-4484-0787Christopher L Wu1 1Anesthesiology, Hospital for Special Surgery, New York, New York, USA 2Anesthesiology, Weill Cornell Medicine, New York, New York, USA 3World Resources Institute, Washington, District of Columbia, USA Correspondence to Dr Christopher L Wu,...
More Than a First Flush: Urban Creek Storm Hydrographs Demonstrate Broad Contaminant Pollutographs
Stormwater runoff clearly impacts water quality and ecological health of urban receiving waters. Subsequent management efforts are often guided by conceptual models of contaminant “first flushes”, defined by disproportionate concentrations or mass loads early in the storm hydrograph.
Educating Patients Regarding Safe Opioid Use After Surgery
close Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Log out Cancel In This Article Abstract and Introduction Abstract In recent years, there have been escalating concerns related to the opioid epidemic. With a steadily increasing opioid supply, it is critical to provide proper education to patients who are prescribed these medications.
Application of Nontarget High Resolution Mass Spectrometry Data to Quantitative Source Apportionment
High resolution mass spectrometry (HRMS) analyses provide expansive chemical characterizations of environmental samples. To date, most research efforts have developed tools to expedite labor- and time-intensive contaminant identification efforts. However, even without chemical identity, the richness of nontarget HRMS data sets represents a significant opportunity to chemically differentiate samples and delineate source contributions.
Road to Recovery: 5 Mental Health Apps to Brighten Your Life
There’s no denying that good mental health today is one of the most important qualities to any individual. After all, how can you go out and seize the day if you cannot muster the energy to get out of bed? While traditional therapy can be costly and time-consuming, there is another solution. Recent medical developments in mobile applications make it simple to find help for any mental health problems you may be encountering.
HES HYCOPTER: The Hydrogen Powered Drone
HES HYCOPTER: The Hydrogen Powered Drone HES Energy Systems, the aerospace company founded in Singapore in 2009, is working to change the electric aerospace industry by optimizing smaller aircraft and drones powered by hydrogen and scaling up. They have worked with other aerospace companies, universities, and government agencies worldwide to solve hydrogen logistic challenges. In the photo: HES Hycopter front. Photo Credits: HES Energy Systems.
Focused assessment with sonography in trauma (FAST) for the regional anesthesiologist and pain specialist
Focused assessment with sonography in trauma (FAST) for the regional anesthesiologist and pain specialist William Clark Manson1, Meghan Kirksey2, Jan Boublik3, Christopher L Wu4 and Stephen C Haskins4 1 Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, USA 2 Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York City, New York, USA 3 Anesthesiology, Stanford Hospital and Clinics, Palo Alto, California, USA 4 Anesthesiology,...
The prescription opioid crisis: role of the anaesthesiologist in reducing opioid use and misuse
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig 1 Inputs into the opioid epidemic. Various factors contribute to the current opioid epidemic. These are not specific to the perioperative period. Fig 2 Potential role of anaesthesiologists in addressing the opioids crisis. Possible areas of intervention for anaesthesiologists in decreasing perioperative opioid use.
Living your Best Life: Six Apps for a Healthier Lifestyle
Living your Best Life: Six Apps for a Healthier Lifestyle Winter is approaching and it is very easy to get lost and feel unmotivated to do anything. But now, is actually the time to ensure you make the most of your available free time to establish a healthier lifestyle. These apps make your life easier by developing sustainable practices that will make you feel happier and more energetic during the day. You may download them by clicking on their name in the article.
Supporting the Workforce: An Interview with Empower Work
Supporting the Workforce: An Interview with Empower Work Difficulties in the workplace have been around for as long as we can remember. From a lack of motivation to harassment to ethical conflicts, the number of potential challenges at work is countless. Unfortunately, the tools available to navigate these tough situations are severely lacking.
Using High-Resolution Mass Spectrometry to Identify Organic Contaminants Linked to Urban Stormwater Mortality Syndrome in Coho Salmon
Urban stormwater is a major threat to ecological health, causing a range of adverse, mostly sublethal effects. In western North America, urban runoff is acutely lethal to adult coho salmon (Oncorhynchus kisutch) that spawn each fall in freshwater creeks. Although the mortality syndrome is correlated to urbanization and attributed to road runoff contaminant(s), the causal agent(s) remain unknown.
Canadian Urological Association best practice report on chronic scrotal pain
You, the Author(s), assign your copyright in and to the Article to the Canadian Urological Association.
Clomiphene citrate rescue of spermatogenesis in men with infertility while remaining on finasteride: A case report
Clomiphene citrate rescue of spermatogenesis in men with infertility while remaining on finasteride: A case report Finasteride is a selective inhibitor of type-2 5-alpha reductase enzyme, preventing the conversion of testosterone to dihydrotestosterone (DHT). Finasteride is used as an oral drug for the treatment of benign prostatic hyperplasia at the 5 mg/day dose and is also used for the treatment of androgenic alopecia, or male pattern hair loss, at a dosage of 1 mg orally.
Contemporary agents in the management of metastatic castration-resistant prostate cancer
NEW FEATURE! CUAJ is now providing readers an opportunity to obtain continuing professional development Section 3 credits of the Maintenance of Certification (self-assessment) program with the Royal College of Physicians and Surgeons of Canada. Simply read the accredited article and answer the short multiple choice questionnaire. Then, enter your email address to receive a certificate of participation from CUA.
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