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Chronix Biomedical

As seen in: Nature, PLOS Medicine, Biomed Central (BMC)
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Articles

Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients - Acta Neuropathologica Communications

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By Chronix Biomedical, Charité-Universitätsmedizin Berlin, Ambulantes Krebszentrum
| Biomed Central (BMC)
Extraction of cfDNA was conducted from 33 CSF samples obtained from 30 patients, including one patient with duplicate samples for technical control (revealing identical results) and two patients with serial CSF samples. While the CSF input volume varied from 0.8 to 3 ml, successful cfDNA extraction was achieved in 26 samples from 23 patients. Seven CSF samples (one control patient and six patients with histologically confirmed CNS tumors) did not yield sufficient cfDNA (> 3 ng) for NGS (Fig.
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Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study

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By Ekkehard Schütz, Anna Fischer, Julia Beck, Chronix Biomedical
| PLOS Medicine Verified
In this study, determination of GcfDNA in plasma by ddPCR allowed for earlier and more sensitive discrimination of acute rejection in LTx patients as compared with conventional LFTs. Potential blood microchimerism was quantitatively low and had no significant influence on GcfDNA value. Further research, which should ideally include protocol biopsies, will be needed to establish the practical value of GcfDNA measurements in the management of LTx patients.
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