Chrysanthy Ikonomidou

Introduction Seizures affect 1 to 4 per 1000 neonates with an incidence as high as 22% in preterm neonates.1, 2 Among neonates with seizures, up to one third of term and half of preterm neonates die, and half of survivors have lifelong disabilities.3 Phenobarbital is the first-line pharmacotherapy for neonatal seizures; however, one third of neonates treated with phenobarbital experience adverse events such as hypotension and respiratory suppression.4 Additionally, phenobarbital may harm the...