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Chrysiis Michaloglou on Muck Rack

Chrysiis Michaloglou

As seen in: Nature
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Articles

Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity

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By Shaon Basu, Sharan K. Bagal, Claire Crafter, Charlene Fallan, Oliver Lemke, Anja Freiwald, Matthew White, Spyros I. Vernardis, Christoph B. Messner, Kenneth Robert Pryde, Antonio Ramos-Montoya, Sophie Regan, Monica C. Rodrigo-Brenni, Sascha Röth, Michael Mülleder, Kevin Moreau, Markus Ralser, Jessica Bosak, Chrysiis Michaloglou, Camilla Ruffilli
| Nature Verified
Abstract Heterobifunctional targeted degraders (HBDs) enable potent removal of protein targets but their clinical success can be hindered by de novo toxicity inherent to their bivalent chemistry. Here we introduce a drug discovery framework that exploits high-throughput proteomics to map and mitigate toxicity mechanisms of emerging drug modalities.
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