Chu-Sook Kim on Muck Rack

Chu-Sook Kim

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Articles

Targeting COL6A3-C5 with nigericin suppresses endotrophin formation and enhances insulin sensitivity in obesity - Experimental & Molecular Medicine

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By Jungsun Yoo, Min Kim, Jin-Pyo An, Won-Keun Oh, Jiyoung Park, Chu-Sook Kim, Woobeen Jo
| Nature
Abstract Endotrophin, a cleavage product of collagen VIα3 (COL6A3), contributes to fibroinflammation in adipose tissue and exacerbates systemic insulin resistance in obesity. Previously, we demonstrated that various hypoxia-induced matrix metalloproteinases (MMPs) are directly involved in the cleavage of COL6A3 to generate endotrophin in obese adipose tissue; thus, inhibition of endotrophin generation by blocking MMP access could be beneficial for treating obesity-related metabolic disease.
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