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Nucleus as Targets of RNA Virus Proteins and Storehouse for Nervous Necrosis Virus Particles Accumulation

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By Vertika Bajpai, Chen-Hung Li, Kuei-Yuan Fang, Chuan-Siang Lai
| preprints.org
Submitted: 19 January 2026 You are already at the latest version Nervous necrosis virus (NNV) is the causative agent of viral nervous necrosis disease in piscine species worldwide. As a positive-sense RNA virus, NNV performs its replication, transcription, translation and assembly in cytoplasm of host cell. However, our immunocytochemistry results show that viral B2 and coat protein translocate into nucleolus in early infection stage.
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