Chuansong Wei

Methods and analysis Study design This study is a prospective, single-centre, non-inferiority, double-blinded, randomised, placebo-controlled trial with three parallel arms (figure 1). It is designed to allocate patients in an intended 1:1:1 allocation ratio to compare the effectiveness of dexmedetomidine and meperidine on the incidence of shivering in patients undergoing off-pump CABG.