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Chuanwei Yin on Muck Rack

Chuanwei Yin

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Mitochondrial DNA release via VDAC1 in keratinocytes: a key driver of innate immunity and vitiligo pathogenesis

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By Jinpeng Lv, wenhui Xu, Peiwen Jiang, Wenhao Yu, Hui Xue, Nan Hu, Yan Cao, Huansha Zhang, Chuanwei Yin, Rongyin Gao
| Nature Verified
Abstract Vitiligo is an autoimmune depigmenting disorder in which oxidative stress is considered a critical trigger of innate immune activation. Although keratinocytes are increasingly recognized as key contributors to disease progression, the mechanism by which they sense and propagate oxidative stress signals has remained unclear. Here, we identify mitochondrial DNA (mtDNA) release as a pivotal event linking oxidative stress to immune activation in keratinocytes.
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