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Chuifang Kong

As seen in: Nature
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Articles

Targeting HAS2 to enhance anti-tumor immunity in pancreatic cancer via PD-L1 regulation

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By Yanchun Fang, Lili Shen, Mengjie Lv, Xinyu Zhang, Hanmeng Xu, Xunxia Bao, Wenjing Ding, Tengfei Yu, Juan Ran, Jiangming Chen, Juling Wang, Dongsheng Hou, Fubao Liu, Yanping Wang, Qiong Li, Daoxiang Zhang, Chuifang Kong, Zhihua Shui, Pengwei Cao, Shengming Ruan
| Nature Verified
Abstract Pancreatic cancer is an aggressive malignancy with poor prognosis and limited treatment options. Recent advances in immunotherapy have shown potential for improving outcomes; however, therapeutic resistance remains a challenge. We demonstrate that HAS2 is significantly upregulated in pancreatic cancer, and is associated with poor prognosis, reduced infiltration of CD4⁺ and CD8⁺ T cells, and shorter survival.
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