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Chuling Hu

As seen in: Nature, Dove Medical Press, Gastrointestinal Endoscopy
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Articles by Chuling Hu

Mevalonate pathway rewiring driven by enhancer remodelling confers resistance to KRAS inhibitors in colorectal cancer

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By Yaoyu Guo, Yi Zhong, Peishan Hu, Yufeng Chen, Wenjun Guo, Jianfeng Chen, Peiyong Guan, Zhengran Zhou, Fang Zhu, Xian Zeng, Jiuping Gao, Zhaoliang Yu, Chuling Hu, Zerong Cai, Xiaoyu Xie, Jason Chan, Wenyu Wang, Dechang Diao, Xiaojun Xia, Qiang Yu, Choon Kiat Ong, Yijun Gao, Xiaojian Wu, Jing Tan, Qiqing Xiong
| Nature Verified
Abstract KRAS inhibitors (KRASi) have emerged as promising new cancer therapeutics for KRAS-mutant cancers; however, resistance remains a potential clinical challenge. Here, we show that reactivation of ERK is a hallmark of KRASi-resistant colorectal cancers (CRCs) and further demonstrate that enhancer remodeling rewires cholesterol biosynthesis through the mevalonate (MVA) pathway to confer this resistance.
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393 UNRAVELING THE IMPACT OF INSOMNIA ON COLORECTAL CANCER: MICROBIOME DYSBIOSIS, IMMUNOSUPPRESSIVE MICROENVIRONMENT, AND THERAPEUTIC IMPLICATIONS

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By Yinmeng Zhang, Du Cai, Jiahui Zhao, He Zhu, Yan Xia, Baowen Gai, Haoning Qi, Chuling Hu, Rende Huang, Mingru Mai, Nan Zhang Verified, Xiao-Jian Wu, Hong Xu, Feng Gao
| Gastrointestinal Endoscopy Verified
Also available on ScienceDirect
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KRAS Inhibitors Are Potential Prophylaxis for Colorectal Cancer Metachronous Metastasis

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By Yaoyu Guo, Chuling Hu, Guojie Long, Du Cai
| Preprints.org
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 18 March 2024 / Approved: 19 March 2024 / Online: 21 March 2024 (03:50:20 CET) Guo, Y.; Hu, C.; Long, G.; Cai, D.; Yu, Z.; Huang, X.; Cai, Z.; Hu, P.; Chen, Y.; Gao, F.; Wu, X. KRAS Inhibitors Are Potential Prophylaxis for Colorectal Cancer Metachronous Metastasis. Preprints 2024, 2024031095.
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Doxorubicin and indoleamine inhibitor for treatment of TNBC

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By Yan Liu, Wei Cao, Shen Gao, Chuling Hu
| Dove Medical Press
Back to Journals » International Journal of Nanomedicine » Volume 19 Authors Hu C , Liu Y, Cao W, Li N, Gao S , Wang Z, Gu F Received 6 October 2023 Accepted for publication 11 January 2024 Published 17 January 2024 Volume 2024:19 Pages 507—526 DOI https://doi.org/10.2147/IJN.S440332 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor R.D.K. Misra Chuling Hu,1,* Yan Liu,2,* Wei Cao,3,* Na Li,4 Shen...
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