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Chung-Chau Hon

As seen in: Nature, BioRxiv, Cell Reports Medicine, Genome Research, Reproductive BioMedicine Online
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Articles

Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation | Nature Communications

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By Jun Inamo, Masaru Takeshita, Jonathan Moody, Chung-Chau Hon, Yoshinari Ando, Takashi Sasaki, Susumu Mitsuyama
| Nature Verified
Abstract Sjögren’s disease (SjD) is an autoimmune disease that causes salivary gland dysfunction due to immune-mediated destruction. While autoantibodies such as anti-SSA and anti-centromere (CENT) are associated with distinct clinical manifestations, the molecular features remain to be elucidated.
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Adverse effects of progestin-primed ovarian stimulation: combination of clinical study and single cell analysis

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By Mika Handa, Tsuyoshi Takiuchi, Chung-Chau Hon, Jonathan Moody, Yasushi Okazaki, Kokoro Ozaki, Masafumi Horie, Yasuhiro Ohara, Takumi Takeuchi, Hidehiko Matsubayashi, Tatsuya Miyake, Tomomoto Ishikawa, Sumika Kawaguchi, Masakazu Doshida, Fumie Saji
| Reproductive BioMedicine Online Verified
Keywords progestin-primed ovarian stimulation inverse probability of treatment weighting single-cell RNA sequencing mitochondrial DNA mural granulosa cell Introduction Despite the increasing number of assisted reproductive technology (ART) cycles performed worldwide, the live birth rate following in vitro fertilisation (IVF) remains relatively low (Adamson et al., 2023), highlighting the importance of selecting an appropriate ovarian stimulation protocol to retrieve competent oocytes.
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Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy

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By Wee Loong Chin, Jonathan Chee, Nicola Principe, Tracy Hoang, Joel Kidman, Yen Yeow, Matthew Jones, Rui Hou, Elena Denisenko, Alison McDonnell, Chung-Chau Hon, Jonathan Moody, Denise Anderson, Sonia Yip, Michelle M Cummins, Martin R. Stockler, Peey-Sei Kok, Chris Brown Verified, Thomas John, Deme Karikios, Kenneth J. O’Byrne, Brett Hughes, Richard Lake Verified, Alistair Forrest Verified, Timo Lassmann, W. Joost Lesterhuis, Alistair M. Cook, Khaing P.W. Hmon, Steven C.-H. Kao
| Cell Reports Medicine Verified
Keywords immune checkpoint therapy ICT platinum chemotherapy mesothelioma single-cell RNA sequencing biomarkers response peripheral blood cancer CD8+ T effector memory cells PD-L1 Introduction Pleural mesothelioma is a rare malignancy linked to asbestos exposure.
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