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Abstract Asthma is a heterogeneous disease characterized by infiltration of immune cells that interact with epithelial cells and release various factors driving chronic inflammation and airway remodeling. Although monoclonal antibody-based biologics alleviate inflammation, their efficacy in suppressing airway remodeling is limited. Interleukin-24 (IL-24) has been implicated in neutrophilic asthma, but its role in eosinophilic asthma remains unclear.
We performed comparative analysis of the public transcriptomic profiling dataset of cholangiocarcinoma (GSE26566) from Gene Expression Omnibus (GEO) database [15]. The raw data were analyzed using Nexus Expression 3 software (BioDiscovery, EI Segundo, CA, USA) with the platform of Affymetrix GeneChip Human Genome U133 Plus 2.0 Array.
Abstract : Obesity and its associated complications are global public health concerns. Metabolic disturbances and immune dysregulation cause adipose tissue stress and dysfunction in obese individuals. Immune cell accumulation in the adipose microenvironment is the main cause of insulin resistance and metabolic dysfunction.
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