Chunxing Li

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CONFLICT OF INTEREST STATEMENT The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. REFERENCES 1, , , et al. Association of variants in two vitamin E transport genes with circulating vitamin e concentrations and prostate cancer risk. Cancer Res. 2009; 69(4): 1429-1438. 2, . Genetic variations in esophageal cancer risk and prognosis. Gastroenterol Clin North Am. 2009; 38(1): 75-91.

1 INTRODUCTION Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by its high degree of aggressiveness, hence presenting a substantial menace to the overall well-being of the population. Despite the progress made in the field of medicine, there has been a consistent increase in the occurrence and fatality rates of PDAC at an average yearly rate of 0.3%. This upward trend may be attributed mostly to shifts in lifestyle patterns, the aging demographic and extended life spans.