Chunying Wang
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Towards an enzyme cascade synthesis of the bulk chemical acrylic acid
Abstract Acrylic acid is a bulk chemical predominantly produced via fossil-based processes. Here, we repurpose and engineer a thiamine diphosphate (ThDP)-dependent enzyme to catalyze direct \({{{\rm{H}}}}_{2}{{{\rm{PO}}}}_{4}^{-}\) elimination from dihydroxyacetone phosphate (DHAP) for acrylic acid synthesis. Quantum chemical calculations reveal the catalytic mechanism involving isomerization, enol-ThDP intermediate formation, \({{{\rm{H}}}}_{2}{{{\rm{PO}}}}_{4}^{-}\) elimination, and hydrolysis.
Opposing Water Effects in Formaldehyde Oxidation Over Palladium/Silicon Dioxide Catalysts via Hydroxyl‐Mediated Electronic Interactions
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available in the main text or the Supplementary material of this article.
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