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Chutian Wu

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Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma | Molecular Cancer | Full Text

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By Weiwei Chen, Yuting Li, Tonghua Wang, Miaoling Huang, Min Wang, Yanfang Chen, Xuyou Liu, Chutian Wu, Linjing Long, Shufen Feng, Shaohui Tang
| Molecular Cancer Verified
We first examined the level of miR-483-5p expression in HCC tissues, and the result showed that miR-483-5p expression significantly up-regulated compared to the MANT (P < 0.01, Fig. 1B). What is more, the expression levels of IGF2 mRNA, H19, and miR-483-5p were also significantly elevated in HCC cells (Huh7 and HCCLM3) compared to those in the normal liver cell (HL-7702), which is similar to the previous studies [21, 22] (Fig. 1C and Figure S1C).
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