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Chyden Chang

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Articles

Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli - Nature Communications

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By Zheng Lian, Minh-Duy Phan, Chyden Chang
| Nature Verified
Abstract Plasmids are major vehicles for the spread of antibiotic resistance genes. Some plasmids additionally carry virulence genes that enhance host pathogenicity. The convergence of resistance and virulence genes on the same plasmid poses significant risk, providing a mechanism to create pathogens that cause severe disease with limited treatment options. Colicin V (ColV)-like plasmids (ColVLPs) are virulence plasmids frequently carried by extra-intestinal pathogenic E.
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