Ciara A. Barr

BACKGROUND: Working dogs exposed to narcotics might require reversal in the field. OBJECTIVE: To explore the pharmacokinetic and pharmacodynamic effects of naloxone administered intramuscularly (IM) or intranasally (IN) to reverse fentanyl sedation in working dogs. ANIMALS: Ten healthy, working dogs aged 1.7 ± 1 year and weighing 26 ± 3 kg. METHODS: In this randomized, controlled cross-over study dogs received either 4 mg of naloxone IN or IM 10 minutes after fentanyl (0.3 mg IV) administration.

AUC 0 ∞ $$ {\mathrm{AUC}}_0^{\infty } $$ area under the plasma concentration versus time curve from zero to infinity AUC % $$ \mathrm{AUC}\% $$ % of AUC 0 ∞ $$ {\mathrm{AUC}}_0^{\infty } $$ extrapolated after the last time point to infinity AUMC 0 ∞ $$ {\mathrm{AUMC}}_0^{\infty } $$ area under the first moment curve extrapolated to infinity Clast last measured concentration Cmax maximum measured plasma concentration F% relative bioavailability IN intranasal Ka absorption rate constant Kel...

Special Feature Article Hope Douglas Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA, 19104 USA Contribution: Writing - original draft, Writing - review & editing Search for more papers by this author Ciara Barr Corresponding Author barr@vet.upenn.edu orcid.org/https://orcid.org/0000-0001-7727-7647 Rood and Riddle Equine Hospital, 2150 Georgetown Road, Lexington, KY, 40511 USA...