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Articles by Ciyang Wang
Genetic Architecture of Cerebrospinal Fluid and Brain Metabolite Levels and the Genetic Colocalization of Metabolites With Human Traits
10.1038/s41588-024-01973-7 Author MSS Humans, Quantitative Trait Loci, Genome-Wide Association Study, Brain, Alzheimer Disease, Polymorphism, Single Nucleotide, Xanthine, Phenotype, Glycine, Metabolome, Waist-Hip Ratio, Parkinson Disease, Tyrosine, Male yes Wang, Ciyang; Yang, Chengran; Western, Daniel; et al., "Genetic Architecture of Cerebrospinal Fluid and Brain Metabolite Levels and the Genetic Colocalization of Metabolites With Human Traits" (2024). Faculty, Staff and Student Publications.
European and African ancestry-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites | Nature Communications
Abstract In this study, we generated and integrated plasma proteomics and metabolomics with the genotype datasets of over 2300 European (EUR) and 400 African (AFR) ancestries to identify ancestry-specific multi-omics quantitative trait loci (QTLs). In total, we mapped 954 AFR pQTLs, 2848 EUR pQTLs, 65 AFR mQTLs, and 490 EUR mQTLs. We further applied these QTLs to ancestry-stratified type-2 diabetes (T2D) risk to pinpoint key proteins and metabolites underlying the disease-associated genetic loci.
Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits - Nature Genetics
Abstract Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide association study for cerebrospinal fluid (CSF) and brain metabolite levels, identifying 205 independent associations (47.3% new signals, containing 11 new loci) for 139 CSF metabolites, and 32 independent associations (43.8% new signals, containing 4 new loci) for 31 brain metabolites.
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s disease | Nature Genetics
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Abstract The integration of quantitative trait loci (QTLs) with disease genome-wide association studies (GWASs) has proven successful in prioritizing candidate genes at disease-associated loci. QTL mapping has been focused on multi-tissue expression QTLs or plasma protein QTLs (pQTLs). We generated a cerebrospinal fluid (CSF) pQTL atlas by measuring 6,361 proteins in 3,506 samples.
By Daniel Western, Chengran Yang, Bridget Phillips, Yueyao Wang, Muhammad Shoaib Ali, Aleksandra Beric, Pat Kohlfeld, John Budde, Allan Levey, Richard Perrin, Agustín Ruiz, Jarod Rutledge, Hamilton OH, Edward Wilson, Yann Le Guen, Lianne M. Reus, Betty M. Tijms, Charlotte Teunissen, Ignacio Álvarez, Tony Wyss-Coray, Yun Ju Sung, Ciyang Wang, David J. Pulford
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