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Muhammad Shoaib Ali

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Articles

Pangenome analysis of salmonella Paratyphi a reveals genetic diversity, antimicrobial resistance determinants, and public health implications

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By Syeda Farishta, Saba Hanif, Rani Faryal, Muhammad Shoaib Ali, Rizwan Uppal, Aftab Khan, Zuhaib Ali, Muhammad Salman, Muzzamil Ahmed, Fahad Khokhar, Mark Holmes, Ajmal Khan, Izzaddinn Elawad Ahmed, S. Tasqeeruddin
| Nature Verified
Abstract Salmonella Paratyphi A (SPA) causing paratyphoid fever, a significant health concern in South Asia, particularly in Pakistan. This research aimed to explore the antibiotic resistance pattern, genetic diversity, and the evolutionary dynamics of SPA isolated from suspected paratyphoid patients in Pakistan. Whole-genome sequencing (WGS) of (n = 10) isolates predicted predominantly serotype O-2, H1: a, H2:1,5.
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Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource

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By Christopher Koch, Shruthi Bandyadka, Brian R Doyon, Daniel Denning, Muhammad Jahanzaib, Muhammad Mian, Muhammad Bilal Liaqat, Lubna Kamani, Nazish Butt, Anjum Jalal, Riffat Sultana, Shahid Abbas, Musfireh Siddiqeh, Muhammad Bilal, Asadullah Khan, Khalid Parvez Babar, Javed Iqbal, Umar Usman, Muhammad Bajwa, Ali Hyder, Muhammad Sadik Memon, Nauman Hashmani, Ambreen Muddassir, Mateen Akram, MUHAMMAD HUSSAIN, Saima Mohsin Verified, Tariq Mehmood, Shahid Mukhtar, Adil Mahmood, Sheraz Khan, Muhammad Khan, Noor ul Hadi, Roshina Anjum, Rehan Abdullah, Muhammad Usman Musharraf, Muhammad Bashir, Muhammad Shoaib Ali, Irfan Majeed, Shahzad Ali Khan, Ikuyo Kou, Wataru Morii, Katherine Smith, Kousik Kundu, Stewart MacArthur, Sebastian Wasilewski, Slavé Petrovski, Juan L Rodriguez-Flores, Moeen Riaz, Manav Kapoor, Joshua Backman, Alan R. Shuldiner, James E. Bradner, Asif Rasheed, John E. Dominy, Allan M Gurtan, Danish Saleheen, Wafa Gul, Aneeqa Bano, Marium Dahar, Namra Saqib, Aflak Rasheed, Faizan Aslam, Mohsin Iqbal Haroon, Samreen Bugti, Abdul Lateef Rodeni, Tahir Rasool, Muhammad Noor Wazir, Rahmat Ghaffar, Sanaullah Jan, Chihiro Hata, Makoto Asaumi, Kieren Lythgow, Igor Splawski
| Nature Verified
Abstract Naturally occurring loss-of-function variants in human genes enable drug target discovery because they mimic pharmacological inhibition of proteins. However, the study of these genetic variants is constrained by their rarity. Sequencing of diverse populations, particularly those enriched in familial relatedness, has been postulated to promote discovery of rare genetic variants1,2,3.
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A prospective observational study evaluating drug-related problems and their impact on patient-related outcomes in hospitalized epileptic patients

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By Muhammad Shoaib Ali, Muhammad Shoaib, Quratulain Khan, Asma Irshad, Shoaib Nawaz
| Nature Verified
Abstract This observational study assessed drug-related problems (DRPs) and their effect on patient-related outcomes (PROs) in 120 hospitalized epileptic patients. Antiseizure medications (ASM) administered included levetiracetam (98%), valproic acid (31%), carbamazepine (18.3%), and phenytoin (16%). Antibiotics such as ceftriaxone (64%), vancomycin (30%), meropenem (31%), and piperacillin-tazobactam (53%) were primarily used to treat hospital-acquired infections (HAIs) and status epilepticus.
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