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Clair Blacketer on Muck Rack

Clair Blacketer

As seen in: Color Research & Application, Nature
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Articles by Clair Blacketer

Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes

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By Chungsoo Kim, Fan Bu, Clair Blacketer, Anna Ostropolets, Talita Duarte-Salles, Benjamin Viernes, Thomas Falconer, Andrea Pistillo, Jing Li, Can Yin, Mui Van Zandt, Paul Nagy, Akihiko Nishimura, Evan Minty, Seng Chan You, Mitsuaki Sawano, Shoko Sawano, Ja Young Jeon, Arya Aminorroaya, Lovedeep S Dhingra, Aline F Pedroso, Phyllis Thangaraj, David A. Dorr, Nicole Pratt, Kenneth K. C. Man, Wallis C. Y. Lau, Daniel Morales, Rohan Khera, Martijn J Schuemie, Patrick Ryan, George Hripcsak, Harlan M. Krumholz, Marc A. Suchard, Yuan Lu
| Nature Verified
Abstract As prescribing of newer antihyperglycemic agents expands, there remains limited comparative safety data for older adults—a population particularly vulnerable to adverse drug events and underrepresented in clinical trials. We conduct a multinational cohort study using nine databases from the U.S. and Europe. Among adults aged ≥65, we compare eighteen safety outcomes across four classes of second-line antihyperglycemic agents.
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Finding treatment‐resistant depression in real‐world data: How a data‐driven approach compares with expert‐based heuristics

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By M. Soledad Cepeda, Janssen Research, Daniel Fife, Clair Blacketer
| Color Research & Application Verified
The definition that best discriminates between subjects with and without TRD considers number of distinct antidepressants (≥3) or antipsychotics (≥1) in the last year. We analyzed 33,336 subjects with no proxy for TRD, and 3,566 with the proxy. Number of antidepressants and antipsychotics were selected in all periods. The best model was at 12 months with an AUC = 0.81. The rule transported well and states that a subject with ≥1 antipsychotic or ≥3 antidepressants in the last year has TRD.
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