To determine the impact of nurse-led follow-up care supporting self-management of people who have had or have cancer. Cancer care is evolving towards enabling people to self-manage the impact of cancer, treatment and overall care on their quality of life (QoL), self-efficacy and distress. A systematic review following Joanna Briggs Institution (JBI) guidance and reported in accordance with the PRISMA statement was undertaken. Four databases were searched, OVID Medline, CINAHL, PsychINFO and Embase.