Key Points Proton pump inhibitors are being increasingly used for the management of gastroesophageal reflux symptoms among children in the United Kingdom. Longitudinal assessments of prescription patterns of proton pump inhibitors are limited in the pediatric population and can help inform clinical research regarding knowledge gaps in this area. General practitioner prescribing of proton pump inhibitors and H2 receptor antagonists changed among children in the United Kingdom between 1998 and 2019.