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3. Results and Discussion 3.1. Examination of Physicochemical Properties of Ibuprofen 3.1.1. Solubility of Ibuprofen in PBS and N-Octanol An API is regarded as suitable for transdermal delivery if its aqueous solubility is greater than 1 mg/mL []. Laboratory testing calculated the aqueous solubility of ibuprofen as 0.651 mg/mL; therefore, API diffusion through the skin might be hindered since low aqueous solubility is not ideal for transdermal delivery.
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