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Articles by Clément Paris
Unravelling the Link between Oligonucleotide Structure and Diastereomer Separation in Hydrophilic Interaction Chromatography Original
Therapeutic oligonucleotides (ONs) have proven effective as a pharmacological strategy toward previously “undruggable” targets by regulating gene expression. (1) Single-stranded antisense ONs (ASOs) and double-stranded small interfering ribonucleic acids (siRNAs) are currently the main ON-based therapeutics undergoing clinical trials. (2) Unmodified nucleic acids often suffer from enzymatic degradation, immune activation, low target affinity, and limited cellular uptake.
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting
(Molecular Cell 79, 710–727; September 3, 2020) In this review, the authors accidentally depicted the wrong structure for sofosbuvir in Figure 2 and Table 2. The correct structure now appears with the article online in both Figure 2 and Table 2. The authors also depict the prodrug structure of NHC in the updated article. The corrected and the original versions of Figure 2 appear below. The authors apologize for the error.
Nucleic Acid-Based Technologies Targeting Coronaviruses
Highlights Nucleic-acid based therapies are worth developing against coronavirus (CoV) outbreaks because of their high specificity and rapid development.
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