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An Osteocartilaginous 3D Printing Implant Using a Biocompatible Polymer and Pre-Differentiated Mesenchymal Stem Cells in Sheep
1. Introduction Articular cartilage permits frictionless joint motion [1]. This tissue has a maximum thickness of 4 mm [2] and its functional units are chondrocytes, which comprise approximately 2% of the total tissue. They are composed of 75–80% water, 15% collagen fibers, and 9–10% proteoglycans, which maintains the integrity of the articular cartilage matrix [3,4]. When the articular cartilage is damaged, a complex condition is generated and the whole joint is affected.
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