Clifford JiaJun He

1 Introduction Medication adherence directly affects therapeutic success and patient outcomes [1, 2]. While higher adherence generally correlates with improved therapeutic effects, the impact of adherence variability differs across medications [3]. In the field of rhinology, chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are among the most common chronic inflammatory conditions, affecting 12.3% of the general population in the United States [4].

1 Introduction Dermal wound healing is a complex, multistep physiologic process requiring coordinated cellular and molecular responses. Numerous tissue-specific and patient-specific factors influence both the rate of wound closure and the final healing outcome [1-3]. Among these, mechanical tension is an important determinant of wound healing dynamics and scar formation [4].

Abstract Neuroblastoma is a leading cause of death in childhood cancer cases. Unlike adult malignancies, which typically develop from aged cells through accumulated damage and mutagenesis, neuroblastoma originates from neural crest cells with disrupted differentiation. This distinct feature provides novel therapeutic opportunities beyond conventional cytotoxic methods.