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Clinic LMU

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KEAP1/NRF2 (NFE2L2) mutations in NSCLC - fuel for a superresistant phenotype?

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By Wolfram Dempke, Martin Reck, Clinic LMU, Lungen Clinic
| Lung Cancer
Abstract The transcription factor NRF2 (nuclear factor E2-related factor 2) (also known as nuclear factor, erythroid 2 like 2 [NFE2L2]) is the master regulator of cellular antioxidant responses. NRF2 is repressed by interaction with a redox-sensitive protein KEAP1 (Kelch-like ECH-associated protein 1).
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