Clovis S. Palmer

Abstract Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys.

Abstract Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting glucometabolic disruptions after acute COVID-19 remains unclear due to the lack of animal models for metabolic PASC. Here, we report a non-human primate model of metabolic PASC using SARS-CoV-2 infected African green monkeys (AGMs).

C.S.P. conceptualized the review, organized and wrote the manuscript, and designed figures. D.C.H., J.J.A., and A.S. wrote and reviewed the manuscript. D.Y. wrote the manuscript and designed figures. B.B. organized and reviewed the manuscript. G.D. reviewed the manuscript and designed figures. M.O. wrote and reviewed the manuscript, designed figures, and made critical comments. C.L.C. and S.M.C. provided intellectual suggestions and critical comments and edited the manuscript.