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Clyde Campbell

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Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells

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By Rachel Wellington, Xiaoyi Cheng, Clyde Campbell, Cole Trapnell
| biorxiv.org
Abstract Hematopoietic stem cells (HSCs) arise in embryogenesis from a specialized hemogenic endothelium (HE). In this process, HE cells undergo a unique fate change termed endothelial-to-hematopoietic transition, or EHT. While induced pluripotent stem cells (iPSCs) give rise to HE with robust hemogenic potential, the generation of bona fide HSCs from iPSCs remains a challenge.
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