CMC API Development

BR bioreactor CFD computational fluid dynamics CHO Chinese hamster ovary CMC chemistry, manufacturing and control DO dissolved oxygen EDR energy dissipation rate Fab fragment monoclonal antibody GBR glass bioreactor GEV gas entrance velocity mAb monoclonal antibody P/V power input per unit volume PP pitched paddle RANS Reynolds-averaged Navier Stokes SSB stainless steel bioreactor SSDM small scale-down model SUB single-use bioreactor VOF volume of fluid 1 Introduction The development timeline...

Rationale mRNA technology has begun to play a significant role in the areas of therapeutic intervention and vaccine development. However, optimizing the mRNA sequence that influences protein expression levels is a resource-intensive and time-consuming process. This study introduces a new method to accelerate the selection of sequences of mRNA for optimal protein expression.