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Cochen De Cock

As seen in: Oxford Academic
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Articles

Presynaptic dopaminergic imaging as a neurodegeneration staging biomarker in the alpha-synucleinopathy continuum

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By Cochen De Cock, Universitat de Barcelona, De Verbizier
| link.springer.com
This large, international, multicenter study aimed to define how DaT-SPECT should be used for staging neurodegeneration along the prodromal to overt neuronal alpha-synucleinopathy continuum at the individual level. Prior work has established DaT-SPECT as a phenoconversion risk marker in prodromal disease stages, but key questions remained about staging across the full disease spectrum and comparing DaT-SPECT with clinical metrics.
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Lack of epistatic interaction of SNCA with APOE in synucleinopathies

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By Gian Luigi, Michele T. M, Cochen De Cock, Christelle Charley
| Oxford Academic Verified
Alpha-synucleinopathy is an umbrella term to describe several neurodegenerative diseases that have a common defining pathological feature, characterized by neuronal or glial inclusions of aggregated alpha-synuclein, known as Lewy bodies, Lewy neurites or glial cytoplasmatic inclusions in the brain.1 Disorders that are collectively referred to as alpha-synucleinopathies include Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA).
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