Colin J. Barnstable

Abstract PEDF has neuroprotective, anti-inflammatory, anti-oxidative stress, and anti-angiogenic actions, but its multifunctional mechanisms remain unclear. We map the developmental distribution of the PEDF receptors LR, LRP6, and ATGL in naïve and Pedf−/− retinas, and define receptor-specific signaling using siRNA and pharmacological inhibition. These receptors are broadly expressed in retinoblasts and acquire cell-type–specific patterns during retinal maturation via PEDF-independent mechanisms.

AD Alzheimer's disease Cont control Hz hertz hr hour ECL enhanced chemiluminescence ELF-EMF extremely low-frequency and low-intensity electromagnetic field FRAP fluorescence recovery after photobleaching MT microtubule MAP microtubule associated protein EB microtubule end binding protein P MT-associated tubulin rcf relative centrifugal force S soluble tubulin SCI spinal cord injury TBI traumatic brain injury Zn zinc 1 Introduction Over the past two decades, noninvasive brain stimulation...

Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, United States Penn State Hershey Eye Center, Hershey, PA, United States Department of Pharmacology, Penn State University College of Medicine, Hershey, PA, United States Center for Cancer Genomics and Precision Oncology, Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC, United States Introduction: Status epilepticus (SE) is a seizure lasting more than 5 min that can have...