Colin Crawford

The TEMPO group is widely employed in organic synthesis, most commonly as a persistent radical trap in mechanistic studies. (11) Beyond this role, well-established methods to install C(sp 3 )-TEMPO groups, particularly those adjacent to carbonyl groups, are known. These include electrochemical and photoredox strategies, as well as enantioselective α-oxyamination reactions mediated by organocatalysis.

Introduction Click to copy section linkSection link copied! Allenes are the simplest cumulenes, comprised of three contiguous unsaturated carbon atoms in the form of two orthogonal alkenes. (1) Their distinctive electronic and geometric features enable the installation of functionality across the entire C1–C3 framework of the allene, positioning these precursors as unique three-carbon synthons in synthesis.

Introduction Click to copy section linkSection link copied! Electrochemistry has recently emerged as a powerful strategy in synthetic chemistry for the construction of valuable chemical motifs. (1) The ability to generate highly reactive radical and radical ion intermediates in a controllable manner under mild, environmentally friendly conditions has inspired the development of numerous electrochemical methodologies for diverse transformations.