Colm A. Ryan

Abstract Synthetic lethality (SL) is an extreme form of negative genetic interaction, where simultaneous disruption of two non-essential genes causes cell death. SL can be exploited to develop cancer therapies that target tumour cells with specific mutations, potentially limiting toxicity. Pooled combinatorial CRISPR screens, where two genes are simultaneously perturbed and the resulting impacts on fitness estimated, are now widely used for the identification of SL targets in cancer.

Colm Ryan · Follow 2 min read · -- I just read an article by Joe Humphreys in the Irish Times that got me thinking. He was talking about the Pareto Principle or the 80/20 rule and how it wasn’t some sort of guide for life, just a general observation on how things in life tends to organise itself. I agree with Joe’s view here, and I just wish to add to it. I’m well accustomed to the 80/20 rule from a business context.

Abstract To solve problems of practical importance1,2, quantum computers probably need to incorporate quantum error correction, in which a logical qubit is redundantly encoded in many noisy physical qubits3,4,5. The large physical-qubit overhead associated with error correction motivates the search for more hardware-efficient approaches6,7,8,9,10,11,12,13,14,15,16,17,18.