Conglian Yang

Green Tea Extract Assembled Nanoclusters for Combinational Photothermal and Chemotherapy “Green chemistry” method is a newly-developing method that using natural products to fabricate drug delivery system, which shows many advantages such as inexpensive, simple, fast and environment-friendly. In this study, we fabricated doxorubicin-loaded gold nanoclusters through a “green chemistry” method, by the use of green tea extract to realize combinational photothermal and chemotherapy against melanoma.

The high mortality of cancer is mainly attributed to multidrug resistance (MDR) and metastasis. A simple micelle system was constructed here to codeliver doxorubicin (DOX), adjudin (ADD), and nitric oxide (NO) for overcoming MDR and inhibiting metastasis. It was devised based on the “molecular economy” principle as the micelle system was easy to fabricate and exhibited high drug loading efficiency, and importantly, each component of the micelles would exert one or more active functions.