Congying Chu

A digital twin of a patient’s brain can forecast how that brain will respond to a treatment before it is ever tried. But forecasting is only the start. The real prize is a twin that tracks the living brain and adjusts therapy moment by moment, choosing the best option for each person.

Abstract Increasing evidence reveals the presence of multimorbidity across physical and mental disorders. A general disease factor (d factor) has been recently identified to capture the shared liability across these conditions, yet its biological basis remains poorly understood. Here, using data from the UK Biobank, we reveal the d factor’s neural, genetic, and environmental underpinnings.

Abstract Both diffusion magnetic resonance imaging and transcriptomic technologies have provided unprecedented opportunities to dissect brain network communication, offering insights from structural connectivity and signaling molecules separately. However, incorporating these complementary modalities for characterizing the interregional communication remains challenging.