Congyu Lu

Conflicts of Interest The authors declare no conflicts of interest. References , , and . 2006. “Two Newborns With Nutritional Vitamin B12 Deficiency: Challenges in Newborn Screening for Vitamin B12 Deficiency.” Haematologica 90, no. 12 Suppl: ECR45. , , , , , and . 2019. “A Co-Ultramicronized Palmitoylethanolamide/Luteolin Composite Mitigates Clinical Score and Disease-Relevant Molecular Markers in a Mouse Model of Experimental Autoimmune Encephalomyelitis.” Journal of Neuroinflammation 16, no. 1: 126.

Abstract Membrane protein ectodomain shedding is a key regulatory mechanism for cell signaling and adhesion, and dysregulated shedding is associated with diseases. More than 70 proteases can catalyze shedding, but the substrate spectra and downstream targets of these "sheddases" remain largely elusive.

Abstract Recent metagenomic studies have identified a vast number of viruses. However, the systematic assessment of the true genetic diversity of the whole virus community on our planet remains to be investigated. Here, we explored the genome and protein space of viruses by simulating the process of virus discovery in viral metagenomic studies.