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Conor DeBarra on Muck Rack

Conor DeBarra

As seen in: BioRxiv
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Articles

Iron deficiency in people with obesity drives defective natural killer cell mitochondrial fitness and function

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By Eimear Ryan, Odhrán K. Ryan, Conor DeBarra, Michelle Sugrue
| BioRxiv
Abstract Natural killer (NK) cells are a population of innate effector lymphocytes, involved in host-defences against viral infections and cancer. Upon activation, NK cells can produce a milieu of cytotoxic molecules and cytokines, which can directly target infected and transformed cells, but also amplify an immune response. Metabolic rewiring underpins NK cell effector functionality, providing the required signals, energy and biointermediates to support their immune responses.
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