Conor Howard

eLife Assessment This important paper presents a rigorous and comprehensive deep mutational analysis of the kinase TYK2, revealing how single amino acid substitutions influence protein abundance, signaling activity, and responses to pharmacological inhibitors.

Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family of non-receptor kinases and plays an essential role in signal transduction of multiple interferon and interleukin cytokine pathways1–3. TYK2 binds to the intracellular domains of cytokine receptors alongside cognate JAK family members.

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