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Abstract Recent advancements in transcriptomics and proteomics have opened the possibility for spatially resolved molecular characterization of tissue architecture with the promise of enabling a deeper understanding of tissue biology in either homeostasis or disease. The wealth of data generated by these technologies has recently driven the development of computational pipelines that, nevertheless, have the requirement of coding fluency to be applied.
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Highlights • Extrasynaptic levels of dopamine in mouse cortex exhibit spontaneous impulses • Impulses are broadly distributed in amplitude and time, with a rate of about 0.01/s • Feedback was used to train mice to volitionally control their spontaneous impulses • Mice learned to reliably modulate dopamine impulses in order to receive a reward Summary 1 Romo R. Schultz W. Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements. J.
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