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Constance Albarracin on Muck Rack

Constance Albarracin

As seen in: Nature, Archives of Pathology
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Articles

Targeting microRNA let-7b-5p-mediated aberrant androgen receptor signaling for prevention of hormone receptor-negative breast cancer

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By Janvi Sandhu, Zhenlin Ju, Constance Albarracin, Jing L. Wang, Anjana Kumari Bhardwaj, Isabelle Bedrosian, Leslie Faye Cando, Leslie Michelle Dalmacio
| Nature Verified
Abstract Androgen receptor, the key mediator of the AR signaling pathway, is expressed in the majority of breast cancers and has been emerging as a potential target for treatment with encouraging results in preclinical and clinical trials. But whether AR plays a role in the preneoplastic context to serve as a target for breast cancer prevention is unknown. Our results showed upregulation of AR expression in the preneoplastic and preinvasive sublines of the MCF10A breast cancer progression model.
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