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Articles by Constance Bordes

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease - Nature Medicine

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By Marie-Gabrielle Duperron, Maria J. Knol, Quentin Le Grand, Tavia E. Evans, Ami Tsuchida, Gennady V Roshchupkin, Jose Romero, Michelle Luciano, Rick M. Tankard, Jean Shin, Nicola J Armstrong, Constance Bordes, Henry Brodaty, Robin Bülow, Ching-Yu Cheng, Jayandra J. Himali, Jiyang Jiang, Shuo Li, Melissa Macalli, Susana Muñoz Maniega, Masakazu Okawa, Tatjana Rundek, Alexander Teumer, Julian Trollor, Katharina Wittfeld, Margaret Wright, Helena Schmidt Verified, Perminder S Sachdev, Wei Wen, Guillaume Bourque, Tomas Paus, Bernard Mazoyer, Yukinori Okada, Hans J. Grabe, Karen A. Mather, Marc Joliot, M. Arfan Ikram, Joanna M. Wardlaw, Sudha Seshadri, Mathieu Bourgey, Yasaman Saba
| Nature Verified
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly in the white matter.
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Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries - Nature

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By Aniket Mishra Verified, Tsuyoshi Hachiya, Shinichi Namba, Daniel Posner, Frederick K. Kamanu, Masaru Koido, Quentin Le Grand, Yunye He, Marios K. Georgakis, Ilana Caro, Kristi Krebs, Yi-Ching Liaw, Felix C. Vaura, Bendik Slagsvold Winsvold, Liisa Tomppo, Gennady V Roshchupkin, Naomi Habib, Jesper Qvist Thomassen, Vida Abedi, Marianne Nygaard, Hampton L. Leonard, Maria J. Knol, Philippe Amouyel, Mark Bakker, Joshua C. Bis, Constance Bordes, Sigrid Børte, Zhengming Chen, Rafael de Cid, Matthias Endres, Leslie E. Ferreira, Natalie Gasca, Vilmundur Gudnason, Jun Hata, Alicia K Heath, Aki S Havulinna, Michael Inouye, Christina E. Jeon, Keith L. Keene, Amit Kumar, Paul Lacaze, Lenore J. Launer, Kaido Lepik, Jiang Li, Ani W Manichaikul, Felipe A. Montellano, Børge G Nordestgaard, Yukinori Okada, Annette Peters, Bruce M. Psaty, Stephen S. Rich, Danish Saleheen, Veikko Salomaa, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia L. Satizabal, Atsushi Shimizu, Yan Sun, Kozo Tanno, Steffen Tiedt, Stella Trompet, Marion van Vugt, Riina Vibo, Kerri L. Wiggins, Huichun Xu, Qiong Yang, Kyungheon Yoon, Christian Gieger, Toshiharu Ninomiya, J. Wouter Jukema, young kim, Ernst Mayerhofer, Joanna M. M. Howson, Hieab H. Adams, Sylvia Wassertheil-Smoller, Kaare Christensen, Mohammad A. Ikram, Tatjana Rundek, Bradford B. Worrall, Janika Kõrv, Ruth Frikke-Schmidt, Karl Georg Haeusler, Peter Heuschmann, Guillaume Pare, Daniel I. Chasman, Teemu J. Niiranen, Myriam Fornage, Sudha Seshadri, Robin G Walters, Mayowa Owolabi, Jennifer Huffman Verified, Lili Milani, Martin Dichgans
| Nature Verified
Author notes These authors contributed equally: Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner These authors jointly supervised this work: Christian T. Ruff, Mayowa O. Owolabi, Jennifer E.
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Stroke genetics informs drug discovery and risk prediction across ancestries - Nature

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By Aniket Mishra Verified, Tsuyoshi Hachiya, Shinichi Namba, Daniel Posner, Frederick K. Kamanu, Masaru Koido, Marios K. Georgakis, Kristi Krebs, Bendik Slagsvold Winsvold, Liisa Tomppo, Gennady V Roshchupkin, Naomi Habib, Vida Abedi, Marianne Nygaard, Hampton L. Leonard, Maria J. Knol, Philippe Amouyel, Mark Bakker, Joshua C. Bis, Sigrid Børte, Zhengming Chen, Rafael de Cid, Matthias Endres, Natalie Gasca, Vilmundur Gudnason, Jun Hata, Alicia K Heath, Aki S Havulinna, Michael Inouye, Keith L. Keene, Amit Kumar, Paul Lacaze, Lenore J. Launer, Kaido Lepik, Jiang Li, Ani W Manichaikul, Børge G Nordestgaard, Yukinori Okada, Annette Peters, Bruce M. Psaty, Stephen S. Rich, Danish Saleheen, Veikko Salomaa, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia L. Satizabal, Atsushi Shimizu, Yan Sun, Kozo Tanno, Steffen Tiedt, Stella Trompet, Kerri L. Wiggins, Huichun Xu, Qiong Yang, Christian Gieger, Toshiharu Ninomiya, J. Wouter Jukema, young kim, Ernst Mayerhofer, Joanna M. M. Howson, Hieab H. Adams, Sylvia Wassertheil-Smoller, Kaare Christensen, Mohammad A. Ikram, Tatjana Rundek, Bradford B. Worrall, Janika Kõrv, Ruth Frikke-Schmidt, Karl Georg Haeusler, Peter Heuschmann, Guillaume Pare, Daniel I. Chasman, Teemu J. Niiranen, Myriam Fornage, Sudha Seshadri, Robin G Walters, Mayowa Owolabi, Jennifer Huffman Verified, Lili Milani, Martin Dichgans, Quentin Le Grand, Yunye He, Ilana Caro, Yi-Ching Liaw, Felix C. Vaura, Jesper Qvist Thomassen, Constance Bordes, Leslie E. Ferreira, Christina E. Jeon, Felipe A. Montellano, Marion van Vugt, Riina Vibo, Kyungheon Yoon
| Nature Verified
Abstract Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2.
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