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Paul Lacaze on Muck Rack

Paul Lacaze

Melbourne
As seen in: Monash University, Color Research & Application, Nature, Yahoo News Australia, ABC News (Australia), The Conversation, SBS, Medical Xpress, The Canberra Times, The Lancet, EconoTimes and
Head - Public Health Genomics, Professor, Monash University, DNA Screen, ASPREE Genomics. Views are my own
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Articles

Diet quality and depressive symptoms in older adults, assessing the effect modification by genetic predisposition and low-grade inflammation: a target trial emulation

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By Belayneh Mengist, Najmeh Davoodian, Mojtaba Lotfaliany, Julie A Pasco, Bruno Agustini, Malcolm Forbes, Wolfgang Marx, Chenglong Yu, Johannes T. Neumann, Paul Lacaze, Alice Owen, John McNeil, John Mcneil, Robyn L. Woods, Michael Berk, Mohammadreza Mohebbi
| Nature Verified
Abstract Longitudinal studies have shown an association between diet quality and depression. However, reverse causality, unmeasured confounding, and selection bias remained important limitations. We aim to examine the relationship between diet quality and depression in older adults while addressing these issues and explore modification role of genetic predisposition to depression and low-grade inflammation. We emulated a target trial of dietary interventions using data from the ASPREE cohort.
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Sepsis risk associated with clonal hematopoiesis of indeterminate potential (CHIP): a secondary analysis of the ASPREE trial

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By Jasmine Singh, Damon P. Eisen, Sean G Byars, Paul Lacaze, John McNeil, John Mcneil, Suzanne G. Orchard, Hayley S. Ramshaw, Rory Wolfe, Erica Wood, Robyn L. Woods, David Curtis, Zoe K. McQuilten, Anna Leichter, James Phung, Le T. P. Thao
| Nature Verified
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of acquired mutations in myeloid neoplasia-associated genes, at a variant allele frequency (VAF) of ≥2%, and in the absence of known myeloid neoplasia or unexplained cytopenia. The prevalence of CHIP increases with age, and it has been associated with many diseases of aging including cardiovascular disease (CVD) [1].
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Personal utility of genomic results: Application and validation of the PrU scale to the Australian context - European Journal of Human Genetics

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By Erin Turbitt, Kris Rogers, Steven Y. He, Jennefer N. Carter, Jane Tiller, Paul Lacaze, Mary-Anne Young, Amanda Willis
| Nature Verified
Abstract The Personal Utility Scale (PrU) was developed in the United States to measure the usefulness of genomic results across self-knowledge, reproductive planning and practical benefits. We aimed to evaluate and validate the model with data from an Australian context. Participants (N = 1526) from a population-based genomic screening study (DNA Screen) completed a survey including the PrU at two time points following receipt of genomic results.
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