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Cooper Grace

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Articles

The global dispersal of visceral leishmaniasis occurred within human history

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By Joao Luis Reis-Cunha, Cooper Grace, Sophia Ahmed, Simon E Harnqvist
| BioRxiv
Abstract The Leishmania donovani species complex (LdSC) causes visceral leishmaniasis (VL), is present in Africa, Europe, the Middle East, Asia and the Americas, and causes 20-40,000 fatalities per year. Previous analyses concluded that dispersal of this species complex occurred 1-10 million years ago.
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Estimating the rate of sexual reproduction and the inbreeding rate in Leishmania

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By Andrew Nicoll, Cooper Grace, Joao Luis Reis-Cunha, Hannah Kilford
| BioRxiv
Abstract Many eukaryotic species undergo sexual reproduction facultatively, either in response to stress or in particular environments. For the remainder of their life cycle they reproduce by mitosis. This facultative sex may be rare, which alters features of their evolutionary dynamics. Both the frequency of sex and the degree of inbreeding have been challenging to estimate from genome-scale polymorphism data.
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