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Cor S. Seinen on Muck Rack

Cor S. Seinen

As seen in: BioRxiv
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Articles

Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes

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By Margarida Viola, Maarten P. Bebelman, Frederik J. Verweij, Cor S. Seinen
| BioRxiv
Abstract Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms driving cardiomyocyte-derived EV (CM-EV) production following stress are poorly understood. In this study, we generated human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) that express NanoLuc-tetraspanin reporters.
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